… the CD8 + T cell response (for example, through immunization) … T cell receptor diversity
across the broader CD8 + T cell … on rapid expansion and lytic function of CD8 + T cells. However, …

… expanding highly functional virus-specific cytotoxic CD8 + T cells, … of TCR signal alone was
sufficient to drive proliferation of … treatment is that in contrast to broadly antigenic HIV vaccines…

… status and function of HIV-specific CD8 + T cells after long-term ART … CD8 + T cells with
high expansion (P<0·0008) and cytotoxic capacity (P=0·02) after in vitro recall, albeit at low cell …

… evidence for antigen-driven clonal expansion in vivo and … T cell responses are broad and
heterogeneous (38, 39), we … To study HIV-1–specific cells, we used overlapping Gag peptides, …

… of anti-viral T cells that show broad cross-reactivity across … /IL2 expansion results in
activation of CD8+ T cells. Washing … -1 vaccine regimens that were designed to elicit HIV-1-specific …

… CD8+ T cell expansion is a common feature of HIV-1 infection… of functional markers in T VM
cells and total CD8+ T cells (Fig… , which enables a broad TCR repertoire and strong immune …

… Within controllers, TCR analysis confirmed shared … before expansion, which was low among
HIV-specific CD8 + T cells … In animal models, transient exposure to antigen via immunization …

… strong and broad T cells targeting functionally important … Our strategy is to focus HIV-1-specific
T cells on the functionally … , MVA is predominantly used for expansion of already primed …

… Latently infected cells can persist through clonal expansion … with a therapeutic vaccine to
strengthen HIV-1-specific T cell … , for example given the far broader effects of TLR8 agonists on …

… types, broadly cross-reactive T cell receptors and epitope targeting, enhanced expansion and
antiviral … (CMV)-vectored SIV vaccines can elicit broad HLA-E-restricted SIV-specific CD8 + …